Clinical Advisory Board
Tranzyme Pharma Proudly Presents Its Clinical Advisory Board
This diverse collection of well-respected and experienced physicians and surgeons confidentially advises Tranzyme Pharma on the clinical direction of its products. The Clinical Advisory Board (CAB) is instrumental in providing clinical guidance as well as strategic advice regarding the development of the Company's pipeline of products. The ultimate objective of the CAB is to help ensure the best treatment options for patients suffering from gastrointestinal and metabolic diseases. The depth and breadth of experience on this board will prove invaluable in shaping the clinical, regulatory, and commercial strategy for Tranzyme Pharma's therapies.
Jean-Paul Castaigne, M.D.
Drug Development Advisor
In addition to his service on the Board, Dr. Castaigne provides the Company with the benefit of his experience in ensuring that all aspects of the pre-clinical and clinical development plans for Tranzyme's lead candidates are properly and adequately addressed.
David J. Drutz, M.D.
Drug Development Advisor
In addition to the leadership provided by Dr. Drutz as Chairman of the Board, he also contributes his breadth of expertise to a critical evaluation of the Company's therapeutic focus and product development plans.
Niels Ejskjaer, M.D., Ph.D.
Physician, Post-Doc Fellow, Aarhus University Hospital, Denmark
Dr. Niels Ejskjaer is Post Doc Fellow at Aarhus University, Aarhus, Denmark where he also serves as a physician in the Department of Medicine at Aarhus University Hospital.
Dr. Ejskjaer's clinical and research interests include clinical characterization and treatment of diabetic complications and gastrointestinal dysfunction, and all aspects of endocrinology. His international visits, clinical and research-wise, include King's College School of Medicine (London, UK), New England Medical Center Hospitals (Tufts University, Boston) and Departments of Neurology and Diabetes at the Mayo Clinic (Rochester, MN).
He completed his medical degree at the University of Aarhus, Denmark, where he also performed his training in Internal Medicine and Endocrinology. His residency was completed at Aabenraa Hospital, Denmark and was followed by a three-year British Diabetic Association clinical research fellowship at King's College School of Medicine, London, whereby Dr. Ejskjaer earned his PhD: "Autonomic Neuropathy in Insulin Dependent Diabetes Mellitus: Autoimmune and clinical aspects".
Per Hellström, M.D., Ph.D.
Professor of Medicine, Karolinska Institutet, Sweden
Dr. Per Hellström is a Professor in Medicine (Gastroenterology and Hepatology), Department of Medicine, at the Karolinska Institutet in Stockholm, Sweden and serves as a Senior Consultant in Gastroenterology and Hepatology, GastroCentre Medicine, Karolinska University Hospital Solna since 2001. Prior to this, Dr. Hellström served as Associate Professor in Pharmacology, Internal Medicine, Gastroenterology, and Hepatology. He also served as a Senior Consultant in Internal Medicine (Gastroenterology and Hepatology), held a research position at Medical Research Council (MFR) and was a Senior Lecturer in Gastroenterology and Hepatology.
Over the years, he has held Associate Editor positions with several international Gastroenterology scientific journals. In total, Dr. Hellström has 221 scientific publications, 20 of which are in manuscript or in press. He has supervised 14 research fellows for a PhD education at Karolinska Institutet
Dr. Hellström received his PhD in Pharmacology in 1985 at the Karolinska Institute; the focus of his thesis was peptidergic regulation of colonic motility and blood flow. He completed his post-doctorate training in the Department of Physiology and Medicine at the Medical College of Virginia. His medical internship and fellowship in Internal Medicine (Gastroenterology and Hepatology) were completed at Stockholms och Jamtlands landsting, Sweden.
Kenneth Koch, M.D.
Professor, Internal Medicine, and Chief, Section of Gastroenterology, Wake Forest University School of Medicine
Dr. Kenneth Koch is a Professor of Internal Medicine and Head, Section on Gastroenterology at Wake Forest University School of Medicine. Prior to his tenure at Wake Forest, Dr. Koch served as Professor of Medicine, Division of Gastroenterology at the Milton S. Hershey Medical Center, Pennsylvania State University. He is a member of many of the major national Gastroenterology professional societies.
Dr. Koch has published over 80 peer-reviewed publications, 5 books and 33 book chapters. He serves as a reviewer for more than 10 scientific journals. Dr. Koch was President of the International Electrogastrography Society, which he co-founded in 1992. Dr. Koch was awarded stature of Best Doctors in America 5 times since 2001 for the areas of gastrointestinal motility and nausea syndromes. Dr. Koch's clinical and research interests include the pathophysiology of nausea and vomiting, gastroparesis, gastric dysrhythmias, and functional dyspepsia. He has authored numerous original works, chapters, and other contributions to the GI literature.
He completed his undergraduate and medical school degrees at the University of Iowa, Internal Medicine training at Milton S. Hershey Medical Center of Pennsylvania State University, and fellowship in Gastroenterology at the University of Florida.
Richard McCallum, M.D.
Professor, Founding Chairman, Department of Internal Medicine, Texas Tech University Health Sciences Center at El Paso
Dr. McCallum has been appointed Professor and Founding Chairman of the Department of Internal Medicine, Texas Tech University Health Sciences Center at El Paso. Prior to coming to TTUHSC, Dr McCallum was Professor of Medicine and Director of the Center for Gastrointestinal Nerve and Muscle Function and Chief of Division of Gastrointestinal Motility, University of Kansas School of Medicine since 2004. From 1996 to 2004, Dr. McCallum was Professor of Medicine Chief, and Program Director, Division of Gastroenterology and Hepatology, University of Kansas Medical Center, Kansas City, Kansas. He also served as attending physician at the Kansas City Veteran’s Administration Medical Center, Missouri.
Before his appointments in Kansas City and Missouri, Dr. McCallum was Professor of Medicine and Program Director, Division of Gastroenterology, Hepatology and Nutrition at the University of Virginia School of Medicine, Charlottesville, Virginia where he was Chief of the Division of Gastroenterology for almost ten years. He was awarded the Paul Janssen Endowed Chair as Professor of Medicine in 1987.
After completing his undergraduate studies at the University of Queensland, he earned his medical degree at the Queensland Medical School in Brisbane, Australia. From there Dr. McCallum began his post graduate studies as a Rotating Intern on the LSU Service at Charity Hospital New Orleans and then a 2 year residency in Internal Medicine at Barnes Hospital in St. Louis.
Dr. McCallum began his gastroenterology career at the University of California (UCLA) where he did his GI Fellowship and then was an attending physician and Assistant Professor of Medicine at the UCLA Hospital for the Health Sciences until 1976. From there, he joined the faculty of Yale University School of Medicine as an Assistant Professor of Medicine and later, as Associate Professor of Medicine. He was attending physician, Yale-New Haven Hospital and Director of Gastroenterology Diagnostic Laboratories, also at Yale-New Haven Hospital from 1976 to 1985.
Dr. McCallum is board certified by the American Board of Internal Medicine with a subspecialty in gastroenterology.
Among his extensive list of professional honors and memberships are Fellow of the American College of Physicians, Fellow of the Royal Australian College of Physicians, Fellow of the American College of Gastroenterology, member of the American Society for Clinical Investigation, President of the Southern Society for Clinical Investigation, & President of the International Electrogastroglam Society. He has also served on several editorial boards and national committees.
Dr. McCallum is the author or co-author of over 450 publications and edited 12 text books. Dr. McCallum’s area of clinical interest and research is the field of gastrointestinal motility, neurogastroenterology and functional bowel disorders. He has been focused on advancing knowledge related to diagnostic approaches, pharmacology and device technology. He is a pioneer in the area of gut electro-physiology and developed the concept of electrical “pacing” of the stomach to treat gastroparesis, particularly related to diabetes mellitus, as well as nausea and vomiting and obesity. He has an NIH grant in this field of gastroparesis which he will be bringing with him to TTUHSC as well as funding from the American Diabetes Association and Pharmaceutical and device companies. Dr. McCallum will bring his research team with him specifically Dr. Irene Sarosiek, will be the Director of Research in GI Neurogastroenterology and Electrical Stimulation and her husband, Jerzy Sarosiek, MD, PhD will continue his laboratory research in addition to being Vice Chair for Research in the department of medicine, providing core lab opportunities for faculty and be a facilitator and catalyst for Research in the Department and collaborative research throughout the school.
Dr. McCallum will be the Medical Director of the new diagnostic center for GI Motility and functional bowel disorders being established at Thomason Hospital as a referral center for patients locally, regionally, and nationally and he will continue to see patients referred for these particular medical problems.
Henry P. Parkman, M.D.
Professor of Medicine, Temple University
Dr. Parkman is Professor of Medicine in the Gastroenterology Section of the Department of Medicine at Temple University. He also holds positions at Temple University as Director of the Clinical Gastroenterology Motility Laboratory, Medical Director of the Office of Clinical Research, and Director of the Clinical Research Unit. In 1996, Dr. Parkman was the Honoree for the Janssen Award for Basic or Clinical Research in Gastrointestinal Motility.
Dr. Parkman's clinical research interests are focused on gastric motility disorders, more specifically, new pharmaceutical treatments for gastroparesis and functional dyspepsia and new diagnostic tests such as breath tests for gastric emptying, electrogastrography (EGG), small bowel motility recordings, and esophageal pH and motility recordings. Further, Dr. Parkman serves on the editorial board of several professional publications such as Digestive Diseases and Sciences, American Journal of Gastroenterology, and American Journal of Physiology. Dr. Parkman has over 100 peer-reviewed publications. His recent research is focused on the effects of fluoxetine, a selective serotonin reuptake inhibitor, on regional gastric contractility and on the detection of JC virus DNA sequences and expression of viral t-antigen and agnoprotein in esophageal cancer.
Dr. Parkman earned his A.B. from Harvard University, Cambridge, MA and his M.D. from Case Western Reserve University, Cleveland, OH. He performed his Internal Medicine training at Johns Hopkins Hospital, and his GI training at the University of Pennsylvania.
Anthony Senagore, M.D.
Professor of Surgery, Michigan State University-College of Human Medicine; Vice President Research and Medical Education, Spectrum Health
Dr. Senagore currently holds the positions of Vice President of Research and Medical Education at Spectrum Health, Professor of Surgery at Michigan State University-College of Human Medicine, and Staff Surgeon at Michigan Medical.
Dr. Senagore's special research focus has been on newer concepts for the enhanced recovery of patients that are undergoing major gastrointestinal surgery. He serves on the editorial board of several domestic and international professional publications such as Diseases of Colon and Rectum, World Journal of Surgery, Current Surgery, and British Journal of Surgery. Dr. Senagore has published more than 120 articles in peer-reviewed scientific journals, 14 textbook chapters, and three textbooks; he has also made over 160 presentations at domestic and international medical conferences. He is a member of several domestic and international surgery related organizations and associations. For the past 7 consecutive years, he has won the Best Doctors in America Award for colon and rectal surgery.
Dr. Senagore earned dual Bachelor of Science degrees from Michigan State University and Wayne State University. He then obtained his M.D. and a Master of Science from Michigan State University and later earned an MBA at the University of Phoenix.
