Tranzyme Pharma is always interested in meeting excellent candidates with experience relevant to any part of our organization. Our company offers a package of competitive compensation and benefits.

Research Triangle Park, NC, USA

     We do not currently have any open positions at the RTP site.

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Analytical Chemists

To support an expansion of our R&D efforts, we have openings for creative and innovative scientists to join our analytical group.

Responsibilities

• Development and validation of HPLC methods for the analysis of small organic molecules, including chiral methodologies
• Purification of library compounds by preparative HPLC
• Residual solvent analysis by GC
• Development and use of methods for the measurement of physicochemical properties of individual compounds such as solubility and log D
• Method development and validation for pharmaceutical analysis
• Stability studies of drug substance and drug product including forced degradation studies
• Maintain up-to-date records for all work performed and ensure a safe workplace

Qualifications

• M.Sc. in Analytical Chemistry with a minimum of 2 years of industrial experience; B.Sc. candidates with at least 5 years of experience will also be considered
• Broad knowledge of current techniques and instrumentation for the analysis of small molecules
• Demonstrated proficiency and expertise in instrumental analytical methods such as HPLC-UV, LC-MS and GC; experience in chiral analysis a plus
• Hands-on experience in preparative HPLC for the purification of organic compounds desired
• Successful record of R&D accomplishments or peer-reviewed publications
• Ability to meet challenging timelines and flexibility to adapt to changing project requirements
• Superior organizational skills with strong computer proficiency
• Good oral and written communication skills including experience with the preparation of standard operating procedures, study protocols and reports
• Excellent interpersonal skills as well as the ability to interact effectively in a dynamic team-oriented environment

Tranzyme Pharma offers a challenging and stimulating environment that rewards team and individual achievements. Please contact us for prompt and confidential consideration:

Tranzyme Pharma Inc.
Human Resources, Job Code T-0903
3001, 12e Avenue Nord
Sherbrooke (Quebec), Canada J1H 5N4
fax: 819-820-6841
jobs@tranzyme.com

Synthetic Chemists: M.Sc. / B.Sc.

To support an expansion of our R&D efforts, we have multiple openings for creative and innovative scientists to join our technical staff.

Responsibilities

• Perform building block and target compound syntheses to support internal and collaborative projects.
• Preparation of these compounds individually or in a library format utilizing both classical solution-phase and solid-phase methods as appropriate. This includes conducting and monitoring reactions, as well as isolation, characterization and purification of the materials obtained.
• Assist in the development of new synthetic processes and improvement of existing procedures to support advanced compound development.
• Maintain up-to-date records for all work performed and ensure a safe workplace.

Qualifications

• B.Sc. or M.Sc. in Organic or Medicinal Chemistry with a minimum of three years of industrial experience required
• At the B.Sc. level, a very good working knowledge of organic chemistry and proficiency in common laboratory techniques are required with an understanding of spectroscopic methods of analysis (NMR, MS, IR, UV) and analytical/separation procedures (column chromatography, reverse-phase chromatography, HPLC) desirable
• At the M. Sc. level, excellent skills in multi-step organic synthesis together with a thorough knowledge of modern purification methods and analytical techniques are expected
• Experience in combinatorial, solid-phase organic or peptide chemistry is highly beneficial
• Commitment to quality work and completion of tasks on schedule
• Ability to meet challenging timelines and flexibility to adapt to changing project requirements
• Good oral and written communication skills plus basic computer proficiency
• Excellent interpersonal and organizational skills as well as the ability to interact effectively in a team oriented environment

Tranzyme Pharma offers a challenging and stimulating environment that rewards team and individual achievements. Please contact us for prompt and confidential consideration:

Tranzyme Pharma Inc.
Human Resources, Job Code T-0902
3001, 12e Avenue Nord
Sherbrooke (Quebec), Canada J1H 5N4
fax: 819-820-6841
jobs@tranzyme.com

Organic/Medicinal Chemists: Ph.D.

To support an expansion of our R&D efforts, we have multiple openings for creative and innovative scientists to join our technical staff in Sherbrooke, QC.

Responsibilities

• Design and execution of multi-step syntheses of new compounds and analogues of existing lead molecules for biological evaluation on milligram to gram scale.
• Conduct appropriate synthetic follow-up studies to optimize bioactivity obtained in support of internal and collaborative programs.
• Optimization of synthetic routes for specific new product candidates.
• Design and construction of focused and targeted chemical libraries for screening in selected biological target systems utilizing parallel synthesis techniques.
• Development and synthesis of novel fragments for incorporation into target molecules.
• Maintain up-to-date records for all work performed and ensure a safe workplace.

Qualifications

• Ph.D. in Organic or Medicinal Chemistry with postdoctoral and a minimum of three years industrial experience
• Demonstrated proficiency and expertise in multi-step synthesis with a thorough knowledge of modern organic chemistry, purification methods and analytical techniques
• Experience in combinatorial, solid-phase organic or peptide chemistry is highly desirable
• Proven track record of scientific achievement, as demonstrated by a successful record of R&D accomplishments and peer-reviewed publications
• Ability to meet challenging timelines and flexibility to adapt to changing project requirements
• Good oral and written communication skills
• Proficiency with computers including standard office programs, use of chemical structure drawing programs, presentation preparation and database searching
• Excellent interpersonal and organizational skills as well as the ability to interact effectively in a team-oriented environment

Tranzyme Pharma offers a challenging and stimulating environment that rewards team and individual achievements. Please contact us for prompt and confidential consideration:

Tranzyme Pharma Inc.
Human Resources, Job Code T-0901
3001, 12e Avenue Nord
Sherbrooke (Quebec), Canada J1H 5N4
fax: 819-820-6841
jobs@tranzyme.com

Process for Application Submission

Please forward a cover letter detailing your interest and qualifications as well as your resume/CV for prompt and confidential consideration:

For positions located in Research Triangle Park, please send to:

Tranzyme Pharma
Human Resources
P.O. Box 13097
Research Triangle Park, NC 27709

Email: jobsrtp@tranzyme.com

For positions located in Sherbrooke, QC, CANADA, please send to:

Tranzyme Pharma
Human Resources, Job Code _____
3001, 12e Avenue Nord
Sherbrooke (Quebec), Canada J1H 5N4

Email: jobs@tranzyme.com

Tranzyme Pharma Agency Policy

Any recruiter or agency seeking to work with Tranzyme must initially contact our Human Resources Department in Research Triangle Park, NC and enter into an approved search agreement. A search agreement must be in place prior to submitting a resume for consideration. Regardless of past practice, any resumes submitted by recruiters or search firms to any employee or representative of Tranzyme, or directly to hiring managers at Tranzyme, in any form without a valid written search agreement in place for that position will be deemed to be the sole property of Tranzyme, and no fee will be paid in the event the candidate is hired by Tranzyme as a result of the referral or through other means.