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Tranzyme
Pharma is
always interested in meeting excellent candidates with
experience relevant to any part of our organization. Our company
offers a package of competitive compensation and benefits.
The following are positions for which we are currently actively
recruiting outstanding candidates:
| Research Triangle Park, NC, USA |
 |
There are no positions currently available.
| Sherbrooke, QC, Canada |
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Tranzyme Pharma does not currently have
any other open positions, but welcomes submission of applications for
future openings by individuals with the following backgrounds:
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Senior Scientist, Medicinal Chemistry |
Location: Sherbrooke, QC, Canada
Responsibilities:
- Plan project specific activities in support of company discovery and development efforts
.
- Analyze biological results and interface with internal pharmacology group to design and plan necessary improvements to lead molecules to achieve targeted candidate profile.
- Design and execute synthesis, purification (flash chromatography, HPLC, crystallization, distillation) and characterization (NMR, IR, GC, LC-MS) of new molecules and analogues of lead candidates (milligram to gram scale) individually or in a library format
.- Design and evaluation of alternative synthetic routes for construction of target molecules.
- Development of route optimization strategies and schemes to permit larger scale synthesis of molecules and fragments
.
- Design and evaluation of new synthetic processes and improvement of existing procedures to support advanced compound development
.- Assist in analysis and technical assessment of new potential targets
.
- Acting as a major technical resource for other scientific staff members
.- Presentation of results internally and externally, including at major scientific conferences.
- Supervision, training and mentoring of multiple junior scientific staff members and ensuring that they perform to an expected level
.- Establishing objectives and planning work for self and direct reports and completion of tasks on schedule.
- Maintain up-to-date records for all work performed and ensure a safe workplace.
Qualifications:
- Ph.D. in Organic or Medicinal Chemistry with a concentration in organic synthesis, including experience with multi-step organic synthesis, with postdoctoral experience preferred.
- Minimum of 3-5 years experience in pharmaceutical or biotech industry
.
- Ability to work in a dynamic environment, high degree of flexibility
.
- Exceptional track record of scientific achievement, as demonstrated by a successful record of R & D accomplishments and peer-reviewed publications
.- Goal-oriented, attention to detail, ability to work in an interdependent team
.
- Excellent team player
.
- Strong people management and leadership skills
.
- Excellent oral and written communication skills
.
- Superior organizational skills
.
- Good computer proficiency including standard office programs, use of chemical structure drawing programs, presentation preparation, project planning tools and database searching.
Location: Sherbrooke, QC, Canada
Responsibilities:
-
Development HPLC methods for
the analysis of small organic molecules, in particular
chromatography using chiral stationary phases.
-
Purification of lead compounds
using a semi-automated preparative HPLC system and
development of procedures for more efficient separations.
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Maintain up-to-date records
for all work performed and ensure a safe workplace.
Qualifications:
- Chemist (B.Sc., M.Sc., Ph.D.) with a minimum of 4 years of experience in HPLC.
Demonstrated proficiency and expertise in HPLC method development.
Experience in chiral chromatography and/or HPLC purification of small organic molecules preferred.
Superior organizational skills with strong computer proficiency.
Good oral and written communication skills.
Excellent interpersonal skills as well as the ability to interact effectively in a dynamic team-oriented environment.
|
Synthetic Chemists:
B.Sc. / M.Sc. |
Location: Sherbrooke, QC, Canada
Responsibilities:
-
Under
the guidance of a senior chemist, perform building block and
target compound syntheses to support internal and
collaborative projects.
-
Preparation of these compounds individually or in a library
format utilizing both classical solution-phase and
solid-phase methods as appropriate. This includes conducting
and monitoring reactions, as well as isolation,
characterization and purification of the materials obtained.
-
Assist
in the development of new synthetic processes and
improvement of existing procedures to support advanced
compound development.
-
Maintain up-to-date records for all work performed and
ensure a safe workplace.
Qualifications:
- B.Sc. or M.Sc. in Organic or Medicinal Chemistry with 0-5
years of experience
- At the B.Sc. level, a working knowledge of organic chemistry
and proficiency in common laboratory techniques are required
with an understanding of spectroscopic methods of analysis (NMR,
MS, IR, UV) and analytical/separation procedures (column
chromatography, reverse-phase chromatography, HPLC) desirable.
- At the M. Sc. level, demonstrated
skills in multi-step organic synthesis together with a
thorough knowledge of modern purification methods and
analytical techniques is expected.
- Experience in combinatorial, solid-phase organic or peptide
chemistry is highly beneficial.
- Commitment to quality work and completion of tasks on schedule
.
- Good oral and written communication skills plus basic computer
proficiency
.
- Excellent interpersonal and organizational skills as well as
the ability to interact effectively in a team oriented
environment.
|
Organic and Medicinal
Chemists: Ph.D. |
Location: Sherbrooke, QC, Canada
Responsibilities:
-
Design
and execution of multi-step syntheses of new compounds and
analogues of existing lead molecules for biological
evaluation on milligram to gram scale.
-
Conduct
appropriate synthetic follow-up studies to optimize
bioactivity obtained in support of internal and
collaborative programs.
-
Optimization of synthetic routes for specific new product
candidates.
-
Design
and construction of focused and targeted chemical libraries
for screening in selected biological target systems
utilizing parallel synthesis techniques.
-
Development and synthesis of novel fragments for
incorporation into biologically active molecules.
-
Maintain up-to-date records for all work performed and
ensure a safe workplace.
Qualifications:
- Ph.D. in Organic or Medicinal Chemistry with postdoctoral preferred and 0-5 years industrial experience
.
- Demonstrated proficiency and expertise in multi-step synthesis with a thorough knowledge of modern organic chemistry, purification methods and analytical techniques.
- Experience in combinatorial, solid-phase organic or peptide chemistry is a plus
.
- Proven track record of scientific achievement, as demonstrated by a successful record of R & D accomplishments and peer-reviewed publications
.
- Good oral and written communication skills.
- Proficiency with computers including standard office programs, use of chemical structure drawing programs, presentation preparation and database searching
- Excellent interpersonal and organizational skills as well as the ability to interact. effectively in a team-oriented environment.
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Process for Application Submission |
Please forward a cover letter detailing your interest and qualifications as well as your resume/CV for prompt and confidential consideration:
For positions located in
Research Triangle Park, NC, please send to:
Tranzyme,
Inc.
Human Resources
P.O. Box 13097
Research Triangle Park, NC 27709
For positions located in
Sherbrooke, QC, Canada, please send to:
Tranzyme
Pharma Inc.
Human Resources
3001, 12e Avenue Nord
Sherbrooke (Quebec), Canada J1H 5N4
Alternatively, ALL applications may be emailed to:
e-mail:
jobs@tranzyme.com
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Tranzyme Pharma Agency Policy |
Any
recruiter or agency seeking to work with Tranzyme must initially
contact our Human Resources Department in Research Triangle
Park, NC and enter into an approved search agreement. A search
agreement must be in place prior to submitting a resume for
consideration. Regardless of past practice, any resumes
submitted by recruiters or search firms to any employee or
representative of Tranzyme, or directly to hiring managers at
Tranzyme, in any form without a valid written search agreement
in place for that position will be deemed to be the sole
property of Tranzyme, and no fee will be paid in the event the
candidate is hired by Tranzyme as a result of the referral or
through other means.
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