Publications

Novel Small Molecule Therapeutics

Ghrelin agonist TZP-101 Improves Symptoms and Gastric Emptying in Diabetic Patients with Gastroparesis

Presented at ACG 2009
Download PDF File

Ghrelin receptor agonist (TZP-101) accelerates gastric emptying in adults with diabetes and symptomatic gastroparesis

Alimentary Pharmacology and Therapeutics 2009
Download PDF File

Contribution of Protein Binding to the Pharmacokinetics of the Ghrelin Receptor Agonist TZP-101 in Healthy Volunteers and Adults with Symptomatic Gastroparesis

Clinical Drug Investigation 2009
Download PDF File

From Libraries of Small Molecule Macrocycles to Drugs

Presented at Drug Discovery Chemistry, April 2009
Download PDF File

Ghrelin Agonist (TZP-101) Effects on Severe Symptomatic Diabetic Gastroparesis

Presented at American Diabetes Association, June 2008
Download PDF File

Ghrelin Agonist (TZP-101): Safety, Pharmacokinetics and Pharmacodynamic Evaluation in Healthy Volunteers: A Phase I, First-in-Human Study

Journal of Clinical Pharmacology 2008
Download PDF File

The motilin receptor antagonist TZP-201 is highly effective in the control of irinotecan induced diarrhea in beagle dogs

Presented at the AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics, October 2007
Download PDF File

Ghrelin Agonist (TZP-101) Gastroprokinetic Action in Diabetic Patients with Gastroparesis: A Pilot Study

Presented at American Diabetes Association, June 2007
Download PDF File

Ghrelin Agonist (TZP-101): Safety, Pharmacokinetics and Pharmacodynamics: A Multi-Dose Evaluation in Healthy Volunteers

Presented at American Motility Society 2007.
Download PDF File

Pharmacological Demarcation of the Central Effects of Ghrelin on Growth Hormone Release and Food Intake with a Novel Ghrelin Receptor Agonist

Presented at ENDO 2007.
Download PDF File

Potent macrocyclic antagonists to the motilin receptor presenting novel unnatural amino acids

Bioorganic & Medicinal Chemistry Letters 2007.
Download PDF File

Prokinetic effects of a new ghrelin receptor agonist TZP-101 in a rat model of postoperative ileus

Digestive Diseases and Sciences 2007.
Download PDF File

Discovery of a New Class of Macrocyclic Antagonists to the Human Motilin Receptor

Journal of Medicinal Chemistry 2006.
Download PDF File

Ghrelin agonist activity in a rat model of postoperative ileus and opioid-delayed gastrointestinal motility

Digestive Disease Week, May 2006.
Download PDF File

Motilin receptor antagonism attenuates naturally occurring MMCs and reverses motilin-impaired gastric accommodation in conscious dogs.

Digestive Disease Week, May 2006.
Download Abstract

Pharmacological separation of the gastrointestinal and endocrine effects of ghrelin using a novel GHS-R1a agonist, TZP-101

20th International Symposium on Neurogastroenterology & Motility. July 2005.
Download Poster

New Approaches to Chemistry Synthesis Methods

High Throughput Parallel Synthesis of Macrocyclic Peptidomimetics.

Presented at American Peptide Symposium 2007
Download PDF File (252KB)

Parallel Solid Phase Synthesis of Macrocyclic Peptidomimetics Using Ru-Catalyzed Ring-Closing Metathesis and a New Application of Cross Metathesis.

Presented at American Peptide Symposium 2007
Download PDF File (234KB)

(2R)- and (2S)-3-Fluoroalanine and Their N-Methyl Derivatives: Synthesis and Incorporation in Peptide Scaffolds.

Organic Letters 2006
Download PDF File (79KB)

Synthesis of Unsaturated Amino Alcohols through Unexpectedly Selective Ru-Catalyzed Cross-Metathesis Reactions.

Organic Letters, 2005, 7: 2113-2116.
Download PDF File (87KB)

Design and synthesis of macro-heterocycles structurally related to tirofiban.

Tetrahedron Letters, 2000, 41: 4737-42.
Download PDF File (237KB)

Design of an organic sequence suitable for the solid phase combinatorial synthesis of libraries of macro-heterocycles.

Tetrahedron Letters, 2000, 41: 4743-49.
Download PDF File (257KB)

Solid phase synthesis of hydroxy-acids leading to macrolactones.

Tetrahedron Letters, 2000, 41: 4751-55.
Download PDF File (168KB)

Solid phase combinatorial synthesis of a library of macro-heterocycles and related acyclic compounds.

Journal of Combinatorial Chemistry, 2000, 2: 615-23.
Download PDF File (126KB)

The transannular Diels-Alder strategy: Applications to total synthesis.

Tetrahedron, 2001, 57: 4243-60.
Download PDF File (556KB)