HitCREATE™ is a library of highly diversified small molecule macrocycles that Tranzyme has created using its MATCH™ technology. HitCREATE™ contains novel and original drug-like compounds with distinct topologies and diverse functionalities, with good representation of lipophilic, polar and charged (acidic and basic) functional groups and high variation of substituents. HitCREATE™ is the first library of synthetic small molecule macrocycles that simultaneously provides chemical and conformational diversity.
MATCH™ (Macrocyclic Template Chemistry) is Tranzyme Pharma's proprietary drug discovery and medicinal chemistry technology. Tranzyme has successfully used this chemistry technology to produce several developmental and clinical stage drug candidates. With MATCH™, for the first time, the construction of synthetic libraries of drug-like, orally administered macrocyclic compounds can be conducted in a highly predictable and efficient manner. MATCH™ is a chemistry breakthrough with broad application to accelerate drug discovery.